PhD Dissertation Discussed in the Department of Chemistry on the Therapeutic Effect of Liposomal Linagliptin Against Streptozotocin-Induced Type 2 Diabetes

Byإعلام كلية التربية للعلوم الصرفة جامعة سامراء Reading Time: 1 minute

 

A PhD dissertation entitled “The Therapeutic Effect of Liposomal Linagliptin Against Streptozotocin-Induced Type 2 Diabetes in Male Laboratory Rats” was discussed in the Department of Chemistry, College of Education for Pure Sciences, University of Samarra. The dissertation was presented by Assistant Lecturer Sama Ali Hussein.

The study aimed to enhance the blood glucose-lowering effect of linagliptin by converting it into a liposomal formulation and evaluating its effect on blood glucose levels in vivo as well as on streptozotocin-induced type 2 diabetes (low-dose model).

The results demonstrated the successful preparation of stable liposomal systems containing linagliptin, which showed high therapeutic efficiency in reducing blood glucose levels and decreasing inflammatory markers and oxidative stress in rats with STZ-induced diabetes. Furthermore, liposomal encapsulation, particularly using phytosterols or corosolic acid, improved the drug’s efficacy, reduced the required dosage, and enhanced its therapeutic effect.

The Media and Government Communication Division extends its congratulations to Assistant Lecturer Sama Ali Hussein on obtaining her PhD degree and advancing in her field of specialization, wishing her continued success and excellence in her scientific and academic career.

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