Two Lecturers at the University of Samarra Publish Joint Scientific Research on Gene Dysregulation and Mutations in a Scopus-Indexed Journal

Assist. Lect. Mustafa Abdulmajeed Abdulkarim and Assist. Lect. Rasha Hameed Jassim, both faculty members at the College of Applied Sciences at the University of Samarra, published a joint scientific paper in the Current Alzheimer Research journal, which is classified as Q3 within the Scopus database.

The research was titled: “A Computational Simulation-Based Multi-Omics Analysis of Alzheimer’s Disease: Investigating the Links Among Gene Dysregulation, Mutations, Protein Networks, and Intrinsic Pathological Mechanisms.”
In their study, the researchers aimed to identify altered genes in the brains of Alzheimer’s patients by analyzing 1,588 differentially expressed genes. Additionally, they focused on the upregulation of immune genes versus the downregulation of genes associated with neuroplasticity, such as Brain-Derived Neurotrophic Factor (BDNF).

The research findings indicated that the Brain-Derived Neurotrophic Factor (BDNF) protein plays a fundamental role in Alzheimer’s disease as a factor affected by both altered gene expression and mutation. Both of these events occur within a biological network centered on the amyloid precursor protein. Furthermore, this mutation showed changes in the BDNF protein structure that contribute to increased amyloid accumulation and neuronal damage.