PhD Dissertation Discussed in the Department of Chemistry on the Determination of Selected Cold Medications Using Chromatographic and Spectroscopic Methods
A PhD dissertation entitled “Determination of Selected Cold Medications Using Chromatographic and Spectroscopic Methods” was discussed in the Department of Chemistry, College of Education for Pure Sciences, University of Samarra. The dissertation was presented by researcher Dhalal Saqban Alwan.
The dissertation aimed to develop and apply an accurate and sensitive spectroscopic method for the determination of a pharmaceutical mixture consisting of Chlorpheniramine Maleate (CPM) and Dexamethasone (DEX) in their pure forms and pharmaceutical formulations. The proposed method was based on the ratio derivative spectrophotometric technique, accompanied by comprehensive validation of the analytical methods in terms of linearity, accuracy, limit of detection (LOD), limit of quantification (LOQ), selectivity, robustness, and precision (repeatability).
The study results demonstrated that the proposed analytical method significantly outperformed the reference method. It also achieved recovery values close to 100% for both CPM and DEX, indicating excellent analytical accuracy. Furthermore, the method exhibited low relative deviation values, reflecting a high degree of repeatability.
