Ph.D. Dissertation at the University of Samarra Studying the Preparation and Characterization of Heterocyclic Derivatives Containing a Carbazole Ring and Evaluating Their Antitumor Activity

A Ph.D. dissertation at the College of Education, University of Samarra, titled “Preparation and Characterization of Heterocyclic Derivatives Containing a Carbazole Ring and Evaluating Their Antitumor Activity and Molecular Docking for Some of Them,” was presented by researcher (Luay Ali Dhahi).

The aim of the researcher’s study was to prepare four different types of chalcones composed of carbazole compounds and heterocyclic rings such as furan and thiophene using conventional methods, and to prepare pyrazoline derivatives from the reaction of the prepared chalcones with four types of hydrazine and its derivatives.

The results showed that the prepared chalcones “L1, L2, L3, L4” exhibited high cytotoxicity against colon cancer cells, with the concentration required to kill the cancer cells reaching the “nanomolar (nM)” range. Additionally, the prepared chalcones demonstrated higher cytotoxicity compared to their pyrazoline derivatives.

The Media and Communications Department at the University of Samarra congratulates the researcher Luay Ali Dhahi (faculty member at the College of Applied Sciences) for achieving this advanced degree in his field and wishes him continued success and progress.