A paper at the University of Samarra evaluates antimicrobial activity; published in Scopus
The international journal of health sciences, classified among the medical journals in Scopus containers, has published a reliable scientific paper by Assistant Professor Dr. Maha Saleh Al-Nuaimi and Maymoona Mazhar Khalaf. The article titled “Preparation and Evaluation of the Antimicrobial Activity of Thiophene Galconate.”
The paper presented the preparation and characterization of the compounds containing chalcone, Schiff bases, and azo dye: which bears the thiophene ring. The compounds (1mk-3mk) were prepared from the reaction of acetophenone derivatives with 2-formyl thiophene, then 2mmk was introduced into two responses: First: it reacted with some benzaldehyde substitutes to prepare Schiff bases (4mk-7mk).
The second was the design of a binary azo dye from phenylenediamine with a salicylic aldehyde to obtain 8 M K and then reacted with 2 M K chalcone to get the 9 M K compound.
The chemical formulas of the prepared compounds were confirmed by spectroscopic methods using UV- and IR spectroscopy, proton, and carbon-13 nuclear magnetic resonance spectroscopy.
The antimicrobial activity against Staphylococcus aureus and Candida albicans has been tested in comparison with neomycin sulfate and nystatin,
Some of the compounds showed up to be good. Moderate inhibition at a concentration of 7.5-10 mg / ml.
