A PhD thesis at Samarra University discusses the evaluation of the sensitivity of the precursor enzyme septilysin and some biochemical markers
The doctoral thesis presented at the College of Education at Samarra University titled “Evaluation of the Sensitivity of Precursor Enzyme Septilysin/Kexin Convertase-9 and Some Biochemical Markers for Inflammatory Response in Patients with Arteriosclerosis” was presented by researcher Muhammad Basim Ahmed.
In his thesis, the researcher aimed to study the effectiveness of the precursor enzyme (septilysin/Kexin Convertase-9), levels of cell adhesion molecules, vascular cell adhesion molecules, along with angiopoietin-like proteins, tumor necrosis factor-alpha, and C-reactive protein.
The study results showed a significant increase at a probability level of “p≤0.001” for the effectiveness of the precursor enzyme septilysin/Kexin Convertase, with cell adhesion molecules, vascular cell adhesion molecules, angiopoietin-like protein, as well as monoamine oxidase enzyme activity. Additionally, the levels of tumor necrosis factor-alpha, C-reactive protein, and markers such as malondialdehyde, peroxynitrite, triglycerides, total cholesterol, and low-density lipoproteins (LDL) were significantly higher in the serum of patients with arteriosclerosis compared to the control group.
