PhD Dissertation at Samarra University Discusses the Synthesis of Nitrogenous Heterocyclic Compounds
A PhD dissertation at the College of Education, Samarra University, titled “Synthesis of Nitrogenous Heterocyclic Compounds and Evaluation of Their Biological Activity,” was presented by researcher Esraa Ismail Saleh.
In her dissertation, the researcher aimed to synthesize a group of compounds containing nitrogenous heterocyclic rings based on pyrrole and pyridine as core structures. The study included an evaluation of their biological activities by synthesizing chalcones (I1–I4) through the reaction of two ketones (4-ethoxyacetophenone and 3,4-methylenedioxyacetophenone) with two aldehydes (pyrrole-2-carboxaldehyde and pyridine-2-carboxaldehyde). Additionally, derivatives of pyrazoline and oxazoline (I5–I24) were prepared through cyclization reactions of the four chalcones using five different cyclization agents.
The researcher achieved several outcomes, including the identification of the synthesized compounds using spectroscopic methods such as FT-IR, 13C-NMR, and 1H-NMR. Furthermore, the biological activity of the compounds (I1–I5) was tested against the parasite Leishmania tropica and human lymphocyte cells.
