PhD Dissertation at the University of Samarra Investigates Analytical and Physical Study of Minoxidil and Carvedilol Used in Hypertension Treatment
A PhD dissertation at the College of Education, University of Samarra, titled “Analytical Estimation of Minoxidil and Carvedilol Used in Hypertension Treatment and Their Physical Study with Evaluation of the Green Chemistry Aspects of the Proposed Methods” was presented by the researcher Shaimaa Abdul Razaq Hussein.
The researcher aimed in her dissertation to develop simple, sensitive, rapid, and cost-effective spectrophotometric methods for estimating Carvedilol and Minoxidil in their pure forms and pharmaceutical preparations. Various analytical techniques were used, including spectrophotometric estimation of Carvedilol via ion-pair complex formation using Alizarin Yellow and Bromocresol Green dyes, along with studying the kinetics of these complexation reactions.
The study results showed adherence to Beer-Lambert’s law within a concentration range of 2–13 µg/mL. The recovery rate (%Rce) for Minoxidil in the presence of Carvedilol ranged from 97.747% to 101.561%, with a relative standard deviation (RSD%) of 0.268%, indicating high accuracy and precision of the proposed methods.
